In contrast, flavopiridol showed little selectivity between cancer and normal cells. Flavopiridol also induced genotoxic stress through the induction of DNA double strand breakage. These results suggest that CDKI 71 has a great potential to be developed as an anti cancer agent.Another study focused on in vitro anti tumour mechanism of CDKI 83, a dual inhibitor of CDK9 and CDKI, was performed in A2780 ovarian cancer cells.
The Monterrey Sultanes stand one game away from a berth in the Serie del Rey (Series of Kings) after winning the first three games of their Mexican League North Division Championship Series over Monclova. Monterrey is seeking their tenth LMB pennant since the team’s 1939 inception while the Acereros are chasing Monclova’s first Liga flag. The two teams have met nine times in the playoffs, with Monterrey winning eight of them while Sutanes skipper Roberto Kelly is trying to outmanage his Monclova counterpart, Pedro Mere, for a LMB North title a second time this year (Mere was dugout boss in Tijuana in the Spring season)..
The Ray Ban Wayfarer is one of those timeless sunglass styles that never gets old. This version with a Classic Blue frame and blue lenses is a great way to show your love for the Pantone Color of the Year, particularly going into spring. We think they’d look great with an all white outfit and your favorite denim jacket..
After 30,000 city residents recently signed a petition to force the Bayview Hunters Point redevelopment plan to a popular vote, the city attorney voided the people will, ludicrously arguing that petition signers had not been given copies of the voluminous redevelopment plan. Ratcliff is supporting Proposition 90, hoping that squelching the power of eminent domain will thwart the San Francisco Redevelopment Agency plan to tear out the heart of yet another black community and replace it with expensive condos, boutiques and 20 bucks a shot sake bars. Her message is that saving California inner urban communities from redevelopment bulldozer should be a higher priority than protecting the pretty beaches, open spaces and low skylines cherished by rich NIMBYs and the bed and breakfast set.
Inspired, we drove 25 minutes more to Lompoc, in search of the less high minded people. From three blocks away, we spotted the most striking building in town, the 1890 House, a tall Queen Anne bed and breakfast inn painted cream and yellow with cobalt and rust colored trim. A white picket fence surrounds the inn, identical to the fence around Egbert Souse’s house in Fields’ film..