Background and Purpose Chronic hypoperfusion in the mouse brain has been suggested to mimic aspects of vascular cognitive impairment, such as white matter damage. Although this model has attracted attention, our group has struggled to generate a reliable cognitive and pathological phenotype. This study aimed to identify neuroimaging biomarkers of brain pathology in aged, more severely hypoperfused mice.Methods We used magnetic resonance imaging to characterize brain degeneration in mice hypoperfused by refining the surgical procedure to use the smallest reported diameter microcoils (160 m).Results Acute cerebral blood flow decreases were observed in the hypoperfused group that recovered over 1 month and coincided with arterial remodeling.
Part of the argument against social media in the workplace and learning place is the paradigm of what should go on in those places. We have separated social interaction from “work” interaction, seeing them as not only different but in conflict. Our society has viewed work and play as being separate and distinct.
The Yi family are largely baffled by the Arkansans they encounter, such as Paul (Will Patton), whose Christian devotion borders on religious mania. Fitting in is hard, prejudice is an ever present specter, but most of the problems the Yi family faces will be familiar to anyone who has seen an episode of The Waltons. Wells run dry, barns catch fire, and the price of produce is never high enough for the farm to run in the black..
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